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Clinical considerations for specific populations: Individuals with diabetes should consult their GP or diabetes specialist before making significant dietary changes, as alterations in carbohydrate intake and meal timing may affect blood glucose control and medication requirements Those taking insulin or sulfonylureas should be particularly cautious, as dietary changes may increase the risk of hypoglycaemia [15] [16] Those with kidney disease should seek medical advice before substantially increasing protein intake People with digestive disorders (such as irritable bowel syndrome) may need to modify fibre recommendations based on individual tolerance Seek urgent medical attention for severe abdominal pain (especially if radiating to the back), persistent vomiting, blood in stool, or symptoms of hypoglycaemia or hyperglycaemia
As ongoing clinical trials evaluate GLP-1R agoinists in individuals with Parkinsons, there is a great deal of preclinical research being conducted in parallel that is attempting to better nail down the mechanisms of action of these drugs
Tirzepatide once weekly for the treatment of obesity in people with type 2 diabetes (SURMOUNT-2): a double-blind, randomised, multicentre, placebo-controlled, phase 3 trial The Lancet, 2023
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