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Moreover, when mice were pre-treated with vehicle or L2-Cmu (20 mg/kg) by intraperitoneal (i.p.) injection, and then challenged with an intravenous (i.v.) bolus of saline or 5 g IGF-1, L2-Cmu was able to modulate IGF-1R activation in vivo, as demonstrated by a near complete inhibition of IGF-1R phosphorylation in lung and ~70% inhibition in heart (Fig

It has also been discovered to be necessary for the development and maintenance of skeletal and muscle tissue, and to raise IGF-1, or Insulin-like Growth Factor 1

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Biochem Genet (2014) 52(1-2):2937