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Given the binary nature of side effect phenotype definitions, we fitted multi-variable logistic regression models (equivalent to a generalized linear model with a binomial family and logit link function)

The ratio of reduced glutathione to oxidized glutathione is often a measure of health, as having high amounts of oxidized glutathione is present in times of extreme stress or injury, shock, and in neurodegenerative diseases

Importantly, these changes were observed without significant reductions in food consumption, pointing to enhanced energy metabolism rather than appetite suppression as the primary mechanism