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Notably, in Kras G12D murine models, inflammatory stimuli accelerate early pancreatic neoplastic transformation through the activation of mTORC1 and mTORC2 complexes, which promote Arp2/3 complex-mediated actin reorganization to synergize with Kras G12D -driven ADM progression in vivo and in vitro [379]
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Nearctic living in the Nearctic biogeographic province, the northern part of the New World
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