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The phase 2 clinical trial, LEAN, investigated the effects of liraglutide on patients with NASH

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Phase 2 liver disease data published in Nature Medicine (2024) identifies retatrutide as the compound with the most comprehensive hepatic fat reduction profile currently under clinical investigation, making it the correct peptide for NAFLD and MASH preclinical study designs

Clinical trials of these medical weight loss drugs have demonstrated significant reductions in body weight, improvements in glycemic control, and favorable effects on cardiovascular risk factors