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According to FDA labeling, no dose adjustment is required in patients with renal impairment, including those with end-stage renal disease (ESRD)

A post-hoc analysis of the four SURMOUNT trials, which included 2,999 women and 1,678 men, found that all doses of tirzepatide produced consistent body weight reductions across both sexes, but women experienced greater percentage weight loss than men

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It enhances insulin secretion in response to meals