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When calories drop sharply, protein tends to drop with them, and protein is what your muscles need to stay intact

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It is therefore important to keep in mind (1) the risk of over-basalization and (2) guideline recommendations that basal insulin therapy should be escalated to combination injectables when the basal insulin dose exceeds 0.5 Units/kg BW/day

That is why we use it selectively, after evaluation, and under medical supervision