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Moreover, to mitigate the risk of confounding by indication, severity of disease and unmeasured participant characteristics, we used an active-comparator design assessing risk of cholangiocarcinoma with sulfonylureas in the primary analyses

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The part of our brain that controls our body weight (hypothalamus) notices any weight loss as starvation and unconsciously works via hormonal signaling to increase hunger and food cravings and decrease calorie burn to get your weight (specifically fat) back to where it was prior to weight loss

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