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Morbidity improvements are generally lower than mortality improvements due to a higher proportion of morbidity incidence (in a critical illness product) being caused by cancers (where the relative risks of incidence by BMI are lower), compared to mortality, with a higher proportion of deaths caused by CVD (where the relative risks by BMI are higher)

Journal of Cellular Physiology

The results demonstrated that BV2-metformin-loaded PLGA treatment reduced TNF- and GFAP expression, confirming suppression of neuroinflammation, while p62 levels were increased, indicating enhanced autophagy