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In 2015, another double-blind RCT reported significant improvements in pain associated with aphthous ulcers with a B12 ointment compared with a B12-free ointment

Alternative dilution: Add 5 ml of BAC water final concentration 1 mg/ml (1,000 mcg/ml) preferred for finer dosing in small-animal protocols

Therefore, RDAs should not be treated as the exact daily dose required, but as a benchmark for the minimum requirement , which in ideal situations can be enough to prevent a deficiency

Ethics declarations Ethics approval and consent to participate Due to the observational nature of this case report, which does not involve any interventions or experimental procedures, formal ethical approval was not required

extend to 16+ weeks for severe suppression