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While injectable B12 is generally considered more effective, oral supplements are an acceptable alternative depending on the needs of the patient
A 2025 joint advisory published in the American Journal of Clinical Nutrition and narrative reviews recommend GLP-1 users consume 1.21.6 grams of protein per kilogram of body weight daily, with intake distributed evenly across meals
Conversely, patients with long-standing obesity, multiple previous weight loss attempts, or significant metabolic dysfunction may benefit from indefinite therapy
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And Ive personally known numerous vegans who neglected B12 and subsequently experienced fatigue and temporary neuropathy that resolved upon supplementation
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