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Additional treatments may be needed for more severe cases
We know that macrocytosis is a very, very late stage of B12 deficiency and that severely deficient patients may not present with this sign, the administration of folic acid also masks macrocytosis by normalising the size of the blood cells
a shorter needle risks depositing the B12 into fat, which slows absorption
For those with a mild deficiency or who can absorb B12 from food, oral Supplements or diet adjustments may be sufficient
Vitamin B12 injections are generally very safe, even at higher doses, because B12 is a water-soluble vitamin
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