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It is a 47-residue synthetic peptide constructed as a D-retro-inverso (DRI) analog: the primary sequence is reversed and each amino acid is substituted with its D-enantiomer, an arrangement that approximates the topological side-chain presentation of the parent L-peptide while conferring markedly greater resistance to proteolytic degradation in typical aqueous and biological buffer systems used at the bench

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Semaglutide and Cardiovascular Outcomes in Patients with Type 2 Diabetes. New England Journal of Medicine , 375(19), 18341844