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To approach the efficacy of BS, dual and triple agonists combining GLP-1 with other entero-pancreatic hormones with complementary actions, including glucose-dependent insulinotropic polypeptide (GIP), glucagon (GCG) and amylin are currently under development [15]
EMPA-REG OUTCOME first demonstrated significant reductions in primary 3-point MACE endpoint, CV mortality, overall mortality, and hospitalization for heart failure (HHF) in its entire cohort and in subgroups with varying baseline renal function and proteinuria 48 , 57
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