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After a median follow-up time of 9.1 months, the use of the GLP-1 receptor agonist-SGLT-2 inhibitor combination was associated with a 57% lower risk of serious renal events (2.0 v 4.6 per 1000 person years

The estimated treatment ratios of the mean AUC 0 of cagrilintide in each of the renal impairment groups to the normal renal function group were 1.23 (90% CI, 0.911.66) for the mild renal impairment group, 1.18 (90% CI, 0.871.59) for the moderate renal impairment group and 1.21 (90% CI, 0.871.68) for the severe renal impairment group

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For longevity, preserving skeletal muscle is critical to avoid sarcopenia and frailty

Berberine on the prevention and management of cardiometabolic disease: clinical applications and mechanisms of action