The liver plays an important role in processing many medications, including semaglutide
Every person is different, so changing medications could help
Discontinuation rates range from 37% to 81% within the first year, driven by cost, side effects, and access barriers, with weight regain thereafter mediated through hormonal dysregulation, CNS maladaptation to reduced GLP-1 signaling, and -cell dysfunction
Others space them out for maintenance
1,2,3 As such, the patients prescribed these medications are much more likely to have been prescribed these medications for diabetes management compared to the patients prescribed the medications and dosages approved for weight loss