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However, the CNS is exposed to many situations that can induce a cell and tissue damage associated with ROS production

There are cumulating data on reduced GSH levels and the consequent increased susceptibility to oxidative stress in many human diseases, contributing to the onset and worsening of these conditions

These targeted microbubbles specifically bind to vascular endothelial cells expressing VCAM-1 in the early stages of IRI, and changes in their ultrasound signals show good correlation with serum and tissue pathological biomarkers [144]

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