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When a patient attempts to engage in physical or cognitive exertion, they demand ATP that simply isn't available, triggering a severe metabolic crash known as post-exertional malaise (PEM)

Genistein administration induced Nrf2 enhancement by activation/phosphorylation of keap1, sirt1, MAPK-ERK1/2, PKC, and estrogen receptor in other cells or tissues, such as: hippocampal tissue, hypothalamic paraventricular nucleus, ovary, and Caco-2 cells [131, 135,136,137]

J Biol Chem (1999) 274:114558

The resulting computational models of virally infected cells were then employed to predict the cellular capacity to produce virions via flux balance analysis 14 and to screen cells for enzymes whose knockout impedes viral replication

Salehi Z, Rajaei F