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The glutathione can then be degraded by the cytoplasmic ChaC family of -glutamylamine cyclotransferases [ChaC1 (ChaC glutathione specific gamma-glutamylcyclotransferase 1) and ChaC2 (ChaC glutathione specific gamma-glutamylcyclotransferase 2)] generating 5-oxoproline and the dipeptide Cys-Gly

Given the uncertainty in the incidence in a highly selected group of CVS patients, the non-inferiority margin was defined based on a proportion (50%) of the Control group rate rather than on a fixed incidence target

it is not a cosmetic, it is not a medicine, it is not intended for use on humans or animals