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What this implies: if the vial remains sealed, in a cool, dry, dark place (ideally under refrigeration or freezing, with minimal humidity), you can reasonably expect 2-3 years of viability in the lyophilized state

Sealed containers with fresh desiccant offer superior humidity protection compared to original vial packaging alone

QligFEP: an automated workflow for small molecule free energy calculations in Q

Oxidative stress can also upregulate the expression of efflux pump-associated genes, enhance the removal of ROS-damaged molecules and ultimately reduce oxidative damage (Grant and Hung 2013)

In the US, a decision is expected later this year for a label extension for the cardiovascular indication for Rybelsus