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1 Introduction Myocardial infarction (MI) remains a significant contributor to morbidity, but mortality has been significantly reduced in the last decades due to the introduction of thrombolytic therapy and acute vascular interventions ( In contrast to the limited self-repair capacity of the adult heart, the heart of newly born mice has a strong regenerative capacity, and the proliferation of the newly formed cardiac tissue comes mainly from the proliferation of endogenous cardiomyocytes ( In recent years, researchers have found that the mammalian heart converts its major metabolic substrate from glucose to fatty acids shortly after birth
2020;53(1):106-14.e5
10.1016/S1474-4422(07)70080-7 23
Together, these findings demonstrate that, in contrast with acute exposure, chronic disruption of iron homeostasis with consequent GSH depletion remodels cellular redox homeostasis over time, inducing a state we term chronoferroptosis: a persistent ferroptotic adaptation characterized by coordinated alterations in iron-handling and antioxidant defense proteins that may represent early vulnerability to neurodegenerative pathology
Empresa especializada en limpiezas y vaciados de fosas spticas, desatascos en general, inspeccin de tuberas y mantenimiento de redes de saneamiento
