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Rojas-Morales, P., Pedraza-Chaverri, J

Glutathione peroxidases (GPXs) such as GPX1 (cytosolic GPX), GPX2 (gastrointestinal GPX), and GPX4 (phospholipid hydroperoxide GPX) catalyze the decomposition of a great variety of peroxides, thus protecting cells against oxidative damage 49,50

Acylation of ghrelin, which is catalyzed by the enzyme ghrelin O-acyltransferase (GOAT), is required for ghrelin to bind to GHS-R1a (Yang et al., 2008)

The mechanism is likely related to reduced caloric intake and metabolic adjustment rather than a direct drug effect

DOI: 10.1056/NEJMoa1603827 [Google Scholar] Marso SP, Bain SC, Consoli A, Eliaschewitz FG, Jodar E, Leiter LA, et al