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In the 1980s, a pilot preclinical study on two rat and monkey PD models 16 and two independent clinical cases 17,18 showed that intracerebroventricular (i.c.v.) administration of dopamine improved motor symptoms, but also resulted in tachyphylaxia, possibly owing to dopamine oxidation despite the use of a preservative solution (sodium metabisulfite), precluding the therapeutic development of this concept
Data were represented as log 2 fold change (log 2 FC) values to each mouse at day 0 (before doxycycline administration)
5-Amino-1MQ binds to and inhibits NNMT, and shuts that leak down
All three treatments are non-invasive, meaning no downtime
Supports brain function and cognitive clarity
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