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For B12, prolonged use of metformin and acid-suppressing drugs (PPIs, H2 blockers) may reduce absorption of oral B12, which is one reason injectable B12 is considered in select patients
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Notably, some suggested that folic acid supplements not only masked vitamin B12 deficiency, but even exacerbated or accelerated it
Although most data is hypothetical, these minor sequence variations could affect a lot
This lipidation promotes albumin binding, extending its plasma half-life to approximately one week, which allows for once-weekly dosing
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