The GLP-1R is a G-protein coupled receptor that has wide tissue expression, including in the brain, the wall of the portal vein near the hilus of the liver, and arteries and arterioles from various organs (kidney, heart, pancreas, and intestine) [18]
Standard ratios: 2mg peptide + 2ml water = 1mg/ml (1000mcg/ml) 5mg peptide + 2ml water = 2.5mg/ml (2500mcg/ml) 5mg peptide + 1ml water = 5mg/ml (5000mcg/ml) 10mg peptide + 2ml water = 5mg/ml (5000mcg/ml) How to choose: More water (2-3ml per vial): Easier to measure small doses accurately Larger injection volumes (0.2-0.3ml) Lasts longer (more injections per vial) Less water (1ml per vial): Higher concentration Smaller injection volumes (0.05-0.1ml) Fewer injections per vial Most people use 2ml of water for 5mg vials
No SAE was considered related to apitegromab, and nausea, fatigue, and headache were among the events reported more often with apitegromab than placebo
This is not a drug, and prescription medication should only be used under the guidance of a licensed healthcare provider
There is no retatrutide-specific discontinuation data published yet