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Peptides fit into the same category because they sound modern, biological and less drug-like

These proteins, known as flippases or FIC1, are involved in maintaining an asymmetric distribution of phospholipids across the canalicular membrane of hepatocytes, thereby protecting the canalicular membrane from hydrophobic BAs and maintaining its integrity

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Chirality, 17 (3), 154-162

Why Hepatic Impairment Matters for Peptide Therapy Liver dysfunction alters drug pharmacokinetics through reduced metabolic capacity, decreased albumin production, portal-systemic shunting, and impaired biliary excretion