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The first is the antioxidant barrier: polyphenols establish antioxidant defense by activating the Nrf2 signaling pathway, and Nrf2 upregulates the expression of HO-1, SOD-1, NQO-1 and other oxidative genes, so as to increase the number of antioxidant enzymes (SOD/CAT/GPX/GSH), and to neutralize cisplatin-induced reactive oxygen species (ROS) and reactive nitrogen species (RNS)
Giri S, Chandra P (2025) Modulation of neuropathological pathways by bioactive peptides and proteins/polypeptides: targeting oxidative stress in neurodegenerative diseases
Studies examining cortisol, growth hormone, and other pituitary hormones have generally not demonstrated clinically significant direct effects, though data are limited
went on the Joe Rogan podcast and announced that roughly 14 of those 19 restricted peptides would be re-categorized such that the FDA would permit them to be compounded once again
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