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The evidence: Unapproved peptides have little, if any, human clinical trial data supporting safety or efficacy

Finally, the FLOW trial may shed further light on the potential mechanisms involved on how GLP-1 receptor agonism could alter renal physiology, combined with future mechanistic studies that aim to find proof for the effects of GLP-1 receptor agonists on the renal risk factors/pathophysiological mechanisms related to DKD as summarized in this review

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SUMOylation refers to a post-translational modification in which small ubiquitin-like modifier (SUMO) proteins are attached to specific sites of a target protein, altering its conformation and activity without inducing degradation [103]