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While it helps regulate energy balance and can mimic the effects of caloric restriction(1), it is a complex molecule to manage

They are also not recommended in individuals with certain conditions such as inflammatory bowel disease, pancreatitis, personal or family history of medullary thyroid cancer or multiple endocrine neoplasia

It safely increases GH and IGF-1, supports 510% fat reduction, boosts lean mass, improves recovery, enhances deep sleep, and promotes daily energy

Although GLP-1RAs seem to have a beneficial influence in reversing many maladaptive brain changes relevant to depression, it should be remembered that at the same time, they are also known to mediate some unfavorable processes such as activation of the HPA axis and intensification of anxiety-like behavior in some animal studies

Note: Monitoring of estrone, estradiol, estriol, and testosterone should be performed with chronic DHEA use