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Reported Sex-Based Variability in the Literature Where sex-based data does appear, researchers generally attribute observed variability to differences in baseline endogenous IGF-1 and growth hormone signaling between male and female physiology, rather than to any fundamental difference in how IGF-1 LR3 binds or activates the IGF-1 receptor

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10.1002/dmrr.3173 Summary Keywords metformin, polycystic ovary syndrome, infertility, mechanism, drug therapy Citation Zeng W, Luo Y, Ou J, Gan D, Huang M, Tomlinson B and Jiang Y (2025) Metformin in polycystic ovary syndrome: unraveling multi-stage therapeutic mechanisms from puberty to long-term health outcomes

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