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Laboratory Corporation of America, Holdings.

The brain, despite representing only about 2% of body weight, consumes approximately 20% of the body's oxygen, generating substantial oxidative stress as a byproduct of its high metabolic activity

Study 2: A randomized clinical trial of 51 patients with chronic musculoskeletal pain were randomized into three groups to the effects of the following on pain intensity and mitochondrial redox status [36]: The primary outcomes included changes in Visual Analog Scale (VAS) pain scores, reduced/oxidized glutathione ratio, and mitochondrial DNA copy number as indicators of redox and mitochondrial status

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