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Physiol Rev 87, 1409-1439
Not recommended for pregnant or breastfeeding women without medical advice
Weight loss and fat burning ultimately depend on calorie balance, training, and consistency
Meta-analysis of randomized controlled trials shows L-carnitine supplementation significantly reduces CRP (weighted mean difference -1.23 mg/L), IL-6 (-0.85 pg/dL), and TNF- (-0.37 pg/dL), with greater effects observed in studies exceeding 12 weeks duration.[4] In obese patients, L-carnitine combined with synbiotics reduced IL-6 by 34%, hs-CRP by 10%, TNF- by 19%, and malondialdehyde by 22%.[5] L-carnitine also improves inflammatory markers in chronic kidney disease, cardiovascular disease, and metabolic conditions.[6] Acetyl-L-carnitine offers distinct advantages for neuroinflammation through multiple mechanisms beyond simple carnitine delivery
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