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Patients with type 2 diabetes, treated with metformin alone or treated with metformin and a second OAD treatment that could be a sulfonylurea or a glinide or a sodium-glucose cotransporter-2 (SGLT-2) inhibitor or a dipeptidyl peptidase-4 (DPP-4) inhibitor, and who were not adequately controlled with this treatment (HbA1c range 7.5% to 10% for patients previously treated with metformin alone and 7% to 9% for patients previously treated with metformin and a second OAD treatment) entered a run-in period for 4 weeks

The simulated time was 12 h

The question is whether combining it directly with tirzepatide in the same vial is the safest way to deliver it

PMID: 29 AtzeniFGerratanaEFrancesco MasalaIBongiovanniSSarzi-PuttiniPRodrguez-CarrioJ

They highlight the need for personalized help, regular check-ins, and good communication between patients and their doctors