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Large randomized controlled trials are needed to assess the efficacy and safety of semaglutide in early-stage symptomatic AD

DOSING REGIMEN We strongly recommend a weekly subcutaneous injection

The STEP (Semaglutide Treatment Effect in People with obesity) clinical trial program, which evaluated once-weekly semaglutide 2.4 mg for weight management, demonstrated significant weight loss (approximately 15% in STEP 1) that could indirectly affect hormone levels, though testosterone was not systematically reported in these publications

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If insulin signalling matters as much in the brain as that work suggests, GLP-1 drugs may not be incidentally helping the brain