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Published pre-clinical studies have used FOXO4-DRI to demonstrate that selective elimination of senescent cells in aged mouse models can improve a range of tissue function parameters including fitness, fur density, renal function, and liver function establishing the broader research principle that senescent cell burden contributes meaningfully to ageing tissue dysfunction and that its targeted reduction produces measurable functional benefits in experimental models
Shortened telomeres are a marker of older age
However, the authors were unable to validate a reduction in SST mRNA expression in human tissue using 10 pairs of tumor and adjacent non-tumorous tissue ( p = 0.074)
The peptide appears to promote formation of granulation tissue and accelerate the transition from inflammatory to proliferative healing phases
No mandatory cycling protocol is required
