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Despite other therapy, gastrointestinal symptoms may fail to resolve if low cobalamin levels are not corrected

First try and fail (or have contraindications for) one of four other prescription drugs approved for weight loss

At full therapeutic doses, roughly 40% of patients experience GI side effects severe enough to consider stopping

Decreased muscle endurance in adult transgenic fish with LMNA mutations In order to assess muscle endurance in adult transgenic zebrafish with LMNA variants and minimize the influence of learned behavior, we conducted a swimming tunnel test for the F1 adult fish

Everyone also followed diet and exercise recommendations alongside their medication, which reflects how these drugs are designed to work in practice