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Clinical Uses Dihydropyridines: Hypertension Angina (stable or variant) Hypertensive emergencies (nicardipine) Subarachnoid hemorrhage (nimodipine) Non-dihydropyridines: Supraventricular arrhythmias (e.g., atrial fibrillation) Angina Hypertension (if no heart failure) Side Effects Dihydropyridines: Headache Flushing Ankle edema Reflex tachycardia Gingival hyperplasia Non-dihydropyridines: Bradycardia AV block Constipation (especially verapamil) Worsening heart failure Contraindications Severe hypotension Heart failure (especially with reduced EF) non-DHPs AV block or sick sinus syndrome Combination of non-DHPs with -blockers (risk of heart block) Drug Interactions Verapamil & diltiazem + -blockers heart block CYP3A4 interactions (e.g., macrolides, statins) To view or add a comment, sign in Modern Retina shared good news for patients with serious retinal disease

Because patients with PD already show reduced levels of protective Trp derivatives, further restriction could exacerbate this deficit and undermine AhR-mediated signaling

It is not recommended for individuals under the age of 18 or over the age of 75

NPI-001 has the potential to treat a broad set of diseases and conditions associated with oxidative stress and reduced glutathione levels such as slowing or stopping disease progression in retinitis pigmentosa patients with functional cones, regardless of their disease-causing genetic mutation

This is crucial as NF-B plays a pivotal role in regulating pro-inflammatory gene expression