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10.1038/tp.2012.143 12 FryeR
In a rodent model of diet-induced inflammation similar to that observed in diabetes, the addition of blueberry powder to the animals diet prevented inflammatory changes, and protected the mice from developing insulin resistance and high blood sugar (DeFuria 2009)
If left untreated, it can lead to an increased risk of serious health problems, including permanent nerve damage
There are two 2HG enantiomers: D-2-hydroxyglutarate (D2HG) and L-2-hydroxyglutarate (L2HG), with the former predominantly generated from IDH1 mutants and PHGDH while L2HG is primarily generated from the promiscuous activity of LDHA and MDH1/2 under hypoxic or acidic conditions and converted back to 2OG by L2HGDH
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