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This mechanism has shown promise in early real-world PCOS cohorts, with patients reporting weight loss, cycle regularity, reduced facial hair, and clearer skin within 1216 weeks

Lixisenatide, a structurally modified derivative of exendin-4, addresses some of these limitations by offering a longer half-life of approximately 3 h, thereby permitting once-daily dosing (Leon et al., 2017)

63,67 However, interpretation of these findings requires caution, as diagnostic confirmation of gastroparesis is challenging, and gastric emptying scintigraphythe diagnostic gold standardis not consistently performed in routine clinical practice

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