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Note: Medication side effects may be underreported

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In certain metabolic disorders, such as obesity and type 2 diabetes, exists a disruption of these finely coordinated systems, where impaired hormonal sensitivity (particularly to leptin and insulin) and altered neurotransmitter function lead to distorted taste perception and maladaptive food preferences (3)

In order to establish the role of AC metabolism in depression risk, we previously [32] leveraged summary-level data from large GWAS (up to ~800,000 samples) and Mendelian randomization analyses to examine the potential reciprocal relationships between circulating levels of 15 ACs and depression