Saxenda vs Retatrutide: What to Do When One Fails At a glance Drug A / Saxenda (liraglutide 3 mg), once-daily subcutaneous injection, FDA-approved 2014 Drug B / Retatrutide, triple GIP/GLP-1/glucagon agonist, Phase 3 trials ongoing as of 2025 Saxenda mean weight loss / approximately 8.0% at 56 weeks (SCALE Obesity, N=3,731) Retatrutide peak weight loss / 24.2% at 48 weeks, 12 mg dose (Jastreboff Phase 2, N=338) Failure threshold / less than 5% body-weight loss after 16 weeks at maximum tolerated dose Primary mechanism difference / Saxenda acts on GLP-1R only
Clinical trials show patients typically lose 15-20% of their starting body weightresults that far exceed what's achievable through diet and exercise alone for most people
Half-life values for the approved compounds come from prescribing information
Zur Strkung der Herzmuskelfunktion kommt es bei Angina pectoris, Herzinsuffizienz und nach Herzinfarkten zum Einsatz
Telomeres are protective caps at the ends of chromosomes that shorten with cell division