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[7, 8] proposed and proved a special aquaporin 4 (AQP4) water channels dependent para-vascular pathway: CSF flows into the brain along PVS and then translocates into the interstitium via AQP4 water channels before exiting along venous perivascular spaces [18, 19]
This provides a plausible basis for synergy when evaluated together in controlled laboratory models
bpm, beats per minute
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