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Compensatory changes in the levels of weight-regulating hormones such as leptin, ghrelin, peptide YY, and gastric inhibitory peptide can counteract diet-induced weight loss, highlighting the difficulty in maintaining weight loss through diet alone [11]

carnitine deficiency will recur quickly without consistent replacement

Protein Synthesis and DNA Repair : It aids in the synthesis of proteins and the repair of DNA, ensuring proper cellular function and replication

Caloric deficit, adequate protein intake, resistance training to preserve lean mass

Critically, these effects were achieved without food intake suppression, distinguishing MOTS-c from GLP-1 receptor agonists whose primary mechanism involves appetite reduction