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Diagnoses were made through a combination of clinical assessments and histological analyses, with none of the patients having received any systemic or topical treatments for a minimum of 2 weeks prior to the biopsy

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Brain-derived neurotrophic factor conditional knockouts show gender differences in depression-related behaviors

Future studies could be improved by defining precise asthma endotypes, involving multiple gene-gene interactions, and increasing sample size and power

This unique sex difference was subsequently confirmed in two follow-up studies, though with more modest reported improvements in female lifespan 7,8 , while a life shortening effect was observed in males 8