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2DF, dose-dependent treatment with SP reduced the proportions of M1-like macrophages as well as increased the proportions of anti-inflammatory M2-like macrophages (mannose receptor CD206 as the phenotypic marker of M2-like macrophages), suggesting that SP inhibited the polarization of proinflammatory M1-like macrophages and promoted the differentiation of anti-inflammatory M2-like macrophages
Eyles, D
And that answer has not changed after reviewing the literature
AMP-activated protein kinase inhibits NF-kappaB signaling and inflammation: impact on healthspan and lifespan
Pevec D, et al
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