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Relaxation of lower esophageal sphincter: Some medications and GLP-1s can affect the lower esophageal sphincter, causing it to relax more than usual
Callander N, Markovina S, Eickhoff J, Hutson P, Campbell T, Hematti P, Go R, Hegeman R, Longo W, Williams E, Asimakopoulos F, Miyamoto S
Participants should have tried to lose weight unsuccessfully before
MOTS-C is a 16-amino-acid mitochondrial-derived peptide that regulates metabolic homeostasis at the cellular level, influencing AMPK signalling, glucose uptake, and lipid metabolism
The presence of an MTHFR polymorphism should therefore be viewed as one factor influencing methylation efficiency rather than evidence that folic acid is ineffective
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