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Entrapment efficiency (EE%) was determined indirectly by centrifuging the nanodispersions at 18,000 rpm for 0.5 h (chitosan NPs) and 1 h (spanlastics vesicles) with a cooling centrifuge (Beckman, Fullerton, Canada) at 4 C

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Although TMA-lyase has been characterized to be responsible for gut microbial choline metabolism [16,17,18,19], the key gut microorganism and the relevant enzyme involved in the conversion of carnitine to TMA remains unclear

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Unlike traditional systemic drugs that suppress the entire immune system, biologics target specific parts of the immune system