glp-1 semaglutide weight loss Is Safe for Loss? GLP-1 weight-loss drugs may also

and you weren't the problem." This shift in understanding opens the door to more comprehensive care

Forrest, Barbara Gordon, Mikel Gray, Robert Dale Mayer, Robert Moldwin, Diane K

Declarations Acknowledgements This work was supported in part by NIA grant R01 AG057381 (Ladiges, PI)

In the STEP and SURMOUNT trials: Constipation was reported in up to 24% of patients on semaglutide 18-23% of patients on tirzepatide experienced constipation It is one of the top three side effects of these medications and is more frequent in those who: Lose weight rapidly Eat low-fiber diets Are female (due to hormonal factors affecting gut motility) Conventional Treatment Approaches Most providers recommend over-the-counter (OTC) remedies such as: Stool softeners (docusate) Fiber supplements (psyllium, methylcellulose) Laxatives (PEG 3350, senna, Mag Citrate) These can help in the short term but do not address the root cause

This leads to IB degradation and the nuclear translocation of NF-B subunits (such as p65/RelA and p50), enabling the transcription of target genes