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Additionally, apigenin exhibits antioxidant activity by increasing superoxide dismutase (SOD), glutathione peroxidase (GPx), and reduced malondialdehyde (MDA) levels in the injured brain (T

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This re-establishment of physiological hypoxia is critical for intestinal homeostasis, as it likely stabilizes the mucosal environment by promoting oxygen-sensitive beneficial commensals while constraining oxygen-tolerant pathobionts.Citation 81 , Citation 82 Together, the coordinated recovery of redox balance, mitochondrial bioenergetics, and tissue hypoxia demonstrates how microbial-driven glutathione oscillations synchronize cellular metabolism with environmental conditions to sustain intestinal health

Kang et al, 1993)