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The authors concluded that these results suggest no benefit of L-carnitine for CVD or its risk factors, with the caveat that the role of endogenous L-carnitine may not correspond to exogenous carnitine from food or supplements.25 A 2022 randomized clinical trial gave 1 g supplemental L-carnitine or placebo twice a day for six months to 157 individuals aged 58 to 75 years with metabolic syndrome
10.1038/sj.embor.7400645 EMBO Rep
This makes the Tylenol question less about the medication itself and more about the interaction between genetics, timing, and environment
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